English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Present work reports an efficient and environmentally benign approach for the synthesis of isoxazole-5(4 H )-ones derivatives using lipase as biocatalyst. The one-pot multicomponent reaction of aldehyde, ethyl acetoacetate, and hydroxylamine hydrochloride at room temperature gives a 3-methyl-4-(hetero) arylmethylene isoxazole-5(4 H )-ones derivatives using water as a solvent. The present protocol has many advantages such as shorter reaction time, excellent yields of products, easy work-up procedure, wide substrate scope tolerance, economical, etc. Moreover, the catalyst (lipase) was recovered and can be reused (up to four to five cycles) without significant loss of its catalytic activity.

Lipase Catalyzed One-Pot Synthesis of 3-Methyl-4-(Hetero) Arylmethyleneisoxazole-5(4 H )-Ones under Aqueous Conditions