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A new series of 1-(5-(4-alkoxy-3-(methylsulfonyl)phenyl)thiophen-2-yl)-5-substituted-3-(trifluoromethyl)-1H-pyrazole have been synthesized by a cyclocondensation reaction of 1,1,1-trifluoropentane-2,4-dione ( 1a ) with (5-(4-methoxy-3-(methylsulfonyl)phenyl)thiophen-2-yl)hydrazine ( 2 ). The structure of 1-(5-(4-alkoxy-3-(methylsulfonyl)phenyl)thiophen-2-yl)-5-substituted-3-(trifluoromethyl)-1H-pyrazole derivatives was characterized by spectroscopic analysis. The synthesized 3-(trifluoromethyl)-1H-pyrazole derivatives were screened for  in vitro  antibacterial activity against  Escherichia coli  (NCIM 2574),  Proteus mirabilis  (NCIM 2388)  Bacillus subtilis  (NCIM 2063) and  Staphylococcus albus  (NCIM 2178) and  in vitro  antifungal activity against  Candida albicans  (NCIM 3100) and  Aspergillus niger  (ATCC 504). The compounds 4-(5-(5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)thiophen-2-yl)-2-(methylsulfonyl)phenol ( 4 ) and 1-methyl-4-(4-(5-(5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)thiophen-2-yl)-2-(methylsulfonyl)phenoxy)pyrrolidin-2-one ( 6e ) showed moderate to good antibacterial and antifungal activity.

Synthesis and Antimicrobial Screening of 3-Fluoromethyl Pyrazole Derivatives