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Herein, it is unprecedentedly reported the synthesis of some new  β -D-ribo and  β -D-2-dexoyribofuranosyl nucleosides of pyrido[2,3-d]pyrimidines derivatives where the sugar moiety is linked to pyrido[2,3-d]pyrimidines  via  S or N glycosidic bond. Therefore, pyrido[2,3-d]pyrimidine derivatives  3  and  6  were utilized as scaffolds to be incorporated with ribose and 2-deoxyribose moieties. The glycosylation reactions were carried out under optimized conditions to enhance the regioselectivity and stereoselectivity during the glycosylation coupling. Various strategies have been applied to afford the desired  N -nucleosides  16  and  19 . Other approaches were utilized to afford the  S -nucleosides  9 ,  13 ,  21 , and  24 . The structural elucidations of the novel nucleosides formed are reported and ascertained by using IR,  1 H NMR,  13 C NMR spectra and microanalysis. All the synthesized compounds were screened against a panel of microorganism strains for antibacterial and antifungal activities as well as antitumor evaluation.

Synthesis and Biological Assessment of New Nucleosides of Pyrido[2,3-d]pyrimidine Derivatives Bearing Ribose and 2-Deoxyribose Moieties