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A new series of 3-(5-aryl-1-phenyl-1H-pyrazol-3-yl)-5-aryl-1,2,4-oxadiazole ( 9a – x ) have been synthesized by a reaction of 5-aryl-N′-hydroxy-1-phenyl-1H-pyrazole-3-carboximidamide ( 7a – d ) with substituted methyl benzoate ( 8a – f ). The newly synthesized 3-(5-aryl-1-phenyl-1H-pyrazol-3-yl)-5-aryl-1,2,4-oxadiazole ( 9a – x ) derivatives were characterized by spectroscopic techniques and screened for  in vitro  antibacterial activity against Gram-positive bacterial strains  Bacillus subtilis  (NCIM 2063),  Staphylococcus albus  (NCIM 2178). Gram-negative bacterial strains  Escherichia coli  (NCIM 2574), it was noticed that compounds  9h ,  9i , and  9j  in which R = 4-Cl and R 1  = 2-Cl/4-Cl or 4-CH 3  showed good activity against  B. subtilis  with MIC 31.25 μg/mL against standard  S. albus  having MIC 7.81 μg/mL.  Proteus mirabilis  (NCIM 2388) and  in vitro  antifungal activity against  Aspergillus niger  (ATCC 504)  Candida albicans  (NCIM 3100). 3-(5-Aryl-1-phenyl-1H-pyrazol-3-yl)-5-aryl-1,2,4-oxadiazole derivatives like compound  9a  (R = H, R 1  = 2-Cl),  9b  (R = H, R 1  = 2-Cl),  9d  (R = H, R 1  = 4-Cl), and  9k  (R = 4-Cl, R 1  = 4-OCH 3 ) showed good activity against  A. niger  with MIC 31.25 µg/mL, which are comparable to standard drug ravuconazole having MIC 31.5 µg/mL. Compounds  9h  (R = 4-Cl, R 1  = 2-Cl) and 9j (R = 4-Cl, R 1  = 4-CH 3 ) showed activity against  A. niger  with MIC 7.81 µg/mL which is comparable to standard drug Fluconazole having MIC 7.81 µg/mL and fourfold more activity with respect to drug Ravuconazole. The antibacterial activity of 3-(5-aryl-1-phenyl-1H-pyrazol-3-yl)-5-aryl-1,2,4-oxadiazole ( 9a – x ) derivatives led to the conclusion that these scaffolds could aid in the creation of lead drugs to treat microbial infection.

Pyrazole Linked-1,2,4-Oxadiazole Derivatives as Potential Pharmacological Agent: Design, Synthesis and Antimicrobial Study