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When derivatives of barbituric acid, tetra aromatic aldehyde bearing ether groups and malononitrile or Meldrum acid have one-pot three-component reactions, the analogous new poly pyranopyrimidine derivatives are formed as poly heterocyclic compounds. Deduction of the structures of the products was performed using their IR,  1 H-NMR, and  13 C-NMR spectroscopy along with CHN analysis. Besides, the synthesized heterocycles were also evaluated concerning their biological activities, including toxicity examination, anti-inflammatory effects, antioxidant activities, and anti-bacterial effects.

Synthesis and Biological Examination of Novel Tetra Pyranopyrimidine Heterocycles Contained Lipophilic Spacers