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A series of new substituted benzimidazole-thiazoles ( 9a–l ) have been designed and synthesized using 2-aminothiazole as a starting material by using molecular hybridization approach. The newly synthesized compounds were characterized by  1 H NMR,  13 C NMR and HRMS analyses. The compounds ( 9a–l ) were evaluated for their  in vitro  antitubercular activity against  Mtb  (MTCC 300) strain. Among the screened compounds  9a ,  9b ,  9c  and  9d  have displayed promising antitubercular activity with MIC 7.55, 4.60, 15.39 and 28.38 μg/mL, respectively. All the compounds were further evaluated for their DPPH radical scavenging activity. The compounds  9a ,  9b  and  9d  were exhibited excellent radical scavenging activity. In addition to this, single crystal structure of compound  9a  was also studied. Furthermore, the high potency of these molecules was supported by ADME properties prediction as well as molecular docking study to gain an insight into the binding mode and affinity toward mycobacterial InhA.

DTP/SiO 2 Assisted Synthesis of New Benzimidazole-Thiazole Conjugates Targeting Antitubercular and Antioxidant Activities