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A new and non-infringing efficient one-pot process for the preparation of catechol-O- methyltransferase (COMT) enzyme inhibitors, entacapone  1  under mild condition, initially reaction of 3-methoxy-4-hydroxy-5-nitro-benzaldehyde  5  with 2-cyano acetic acid  13  in presence of new organic base benzyl Trimethyl ammonium hydroxide, i.e. Triton-B which undergo Knoevenagel condensation to get intermediate  22  which is then react with SOCl 2  to get chloride intermediate  23  and which undergo condensation with diethylamine to get  6  and finally deprotection in presence of HBr-AcOH to get economically efficient and industrially feasible entacapone  1  with higher purity and yield without isolation of any intermediate as compared to conventional batch wise process.

Non-Infringing Efficient One-Pot Process for the Preparation of Pure Entacapone