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A novel series of benzene sulfonamide pyrazole oxadiazole derivatives have been synthesized by reaction of 4-(5-(3-fluoro-4-methoxyphenyl)-3-(hydrazinecarbonyl)-1H-pyrazol-1-yl) benzene sulfonamide with different substituted benzoic/pyridinyl/indolyl acids in phosphorous oxychloride, characterized by IR,  1 H NMR,  13 C NMR, MS analytical data and evaluated for their antimicrobial as well as antitubercular activity. Molecular docking studies against  Mycobacterium tuberculosis  β-ketoacyl-acyl carrier protein synthase A, (Kas-A) was carried out to understand the possible mode of its inhibition and potential of synthesized compounds as antitubercular agents. Antibacterial activity of compounds  5d ( 3-Cl )  and  5f  (2,4-diCl) were found good against  E. coli ,  P. aeruginosa ,  S. aureus  and  S. pyogenes  as compared to standard Ampicillin. Compound  5d  was found active antitubercular agents against  M. tuberculosis  H 37 Rv.

polycyclic aromatic compounds

Docking Simulations and Primary Assessment of Newly Synthesized Benzene Sulfonamide Pyrazole Oxadiazole Derivatives as Potential Antimicrobial and Antitubercular Agents