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An eco-friendly, sustainable, simple, and facile protocol has been demonstrated for the synthesis of some novel perimidine derivatives using readily available 1,8-diaminonaphthalene and substituted aldehydes in the presence of green carbocatalyst, graphene oxide (GO). The designed protocol was efficiently carried out under metal-free conditions at room temperature through simple shaking and the desired products were obtained in high to excellent yields in short reaction time (50 sec-2 min) using low catalyst loading (0.005 g). A library of derivatives was synthesized that accomplished high functional group tolerance of the designed protocol. The antimicrobial activity of synthesized compounds was performed against Gram-negative bacteria ( E. coli  ATCC 25922 and  P. aeruginosa  ATCC 27853), Gram-positive bacteria ( S. aureus  ATCC 25923 and  B. subtilis  ATCC 6633) and fungus ( A .  niger  ATCC 16404) using broth micro dilution method. The present methodology displays many advantages such as high product yields, very less reaction time, wide substrate scope, and simple work-up procedure.

Graphene Oxide as Metal-Free Catalyst in the Two-Component Reaction to Generate Some Novel Perimidines and Antimicrobial Evaluation