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Chrysin, a natural flavonoid, has been investigated for its anticancer biological properties. Antifungal and anticancer properties of hydrazone derivatives have been proven. In this study, eight compounds of substituted Chrysin hydrazine derivatives have been designed, synthesized, and screened against cancerous cell lines, including MCF-7 and HepG-2. All products are reported for the first time. Most compounds exhibited significant cytotoxic activity against selected cell lines. The chemical structures of all compounds were confirmed by spectroscopic methods and elemental analyzes.  In vitro  evaluation of these synthesized compounds showed most of them have potential antiproliferative activity. Compounds 3e and 3f have shown significant anti-proliferative activity against MCF-7 and HepG-2 cell lines, respectively, compared to Chrysin ( P  &lt; 0.05). The IC 50  values of compounds  3e  and  3f  were 101.44 and 166.19 µM after 48 h, respectively. Moreover, the compounds 3e and 3f induced significant apoptosis more than Chrysin ( P  &lt; 0.05). The Results of this research might help the design and synthesis of novel drugs toward developing new antitumor agents for cancer treatment.

Green Synthesis and Anticancer Evaluation of Novel Chrysin Hydrazone Derivatives