English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

A new series of bi, tri-podal quinoline derivatives were synthesized by treating substituted phenols of (2-phenoxyquinolin-3-yl)methanols ( 5a–j ) with the brominating reagents such as 1,2- bis (bromomethyl)benzene ( 6 ) and 1,3,5- tris (bromomethyl)-2,4,6-trimethylbenzene ( 8 ) in the presence of NaH as a base, afforded bi-podal ( 7a–j ) and tri-podal ( 9a–j ) quinoline derivatives respectively. All the newly synthesized compounds ( 7a – j  and  9a – j ) were found to be obtained with good yield in lesser time. Generally, single quinoline core moiety possessing molecules are biologically active and were displayed wide range of applications in medicinal field, but here we have synthesized molecules with two, three quinoline moiety, and expect that definitely they may play a greater role in medicinal activities compared with single quinoline possessed molecules and all the newly synthesized bi, tri-podal molecules were subjected to molecular docking studies with alpha-amylase and alpha-glucosidase enzymes to envisage the binding efficacy with comparative studies of standard drug acarbose.

polycyclic aromatic compounds

A Diversity-Oriented Concise Synthesis of a New Class bi, Tri-Podal Quinoline Derivatives with Their In Silico Alpha-Amylase and Alpha-Glucosidase Binding Studies