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Novel, a series of pyrrolyl-thio alkylated/aryl alkylated benzimidazole derivatives were synthesized  via  one-pot, the three-component reaction of 5-amino-2-mercaptobenzimidazole, 2,5-dimethoxytetrahydrofuran, and different substituted alkyl/aryl alkyl halides in acetic acid and sodium acetate is described. The newly synthesized scaffolds were purified and confirmed by their spectroscopic (IR,  1 H-NMR,  13 C-NMR, Mass) and elemental analysis. Further,  in silico  molecular docking studies were carried out for the synthesized compounds against the colchicine binding site of α β -tubulin (PDB ID: 1SA0). Among all the synthesized compounds  4j ,  4p  was shown good binding affinity with colchicine binding site of α β -tubulin.

polycyclic aromatic compounds

A Facile One-Pot Synthesis of Benzimidazole-Linked Pyrrole Structural Motifs  via  Multicomponent Approach: Design, Synthesis, and Molecular Docking Studies