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An efficient, one-pot multicomponent synthesis of 3-amino-1-alkylpyridin-2(1 H )-one as privileged medicinal scaffolds was achieved by condensation of N-Alkyl-2-cyanoacetamides, aldehydes, and malononitriles in the presence of 1,8-diazabicyclo [5,4,0] undec-7-enium acetate [DBUH][OAc] ionic liquid, which acts as a green solvent medium. Mild conditions with outstanding conversion and simple isolation procedure are significant advantages of this method. The recyclability and recovery of the ionic liquid make this protocol environmentally desirable. Also, a series of (aryl or het) 2-dihydropyridine-3,5-dicarbonitrile derivatives were evaluated for their in vitro antitumor activity against three human cancer cell lines MCF-7/AZ, HeLa, and Jurkat with promising activity.

polycyclic aromatic compounds

Rapid Multicomponent Tandem Annulation in Ionic Liquids: Convergent Access to 3-Amino-1-Alkylpyridin-2(1 H )-One Derivatives as Potential Anticancer Scaffolds