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Substituted Olefin-based compounds are attractive targets in the design of novel chemical structures for the discovery of new drugs. In the current study, we have synthesized a series of new tri-substituted olefin derivatives  (4a–4p)  and their chemical structures were confirmed by spectroscopic techniques. The series of molecules were evaluated for anti-cancer potential against four human cancer cell lines such as MDA-MB-232, HepG2, MCF-7 and HEK293. Among the evaluated compounds, ten compounds  4a ,  4c ,  4d ,  4f, 4g, 4h, 4k, 4l, 4m  and  4p  displayed more potent anticancer activity. Along with anti-cancer we evaluated antimalarial activity of all compounds toward plasmodial strain PF3D7 via SYBR Green I assay approach and screened their Anti tuberculosis interest toward Mycobacterium tuberculosis.

polycyclic aromatic compounds

Synthesis of Tri-Substituted Olefin Derivatives from 1-Alkene-1,2-Diboronic Esters  via  Sequential Suzuki-Suzuki Coupling Reaction and Their Biological Activity