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Various benzothiazole derivatives were synthesized by allowing 2-cyanomethylbenzothiazole ( 1)  or its arylidene derivatives to react with diverse reagents under different simple and efficient reaction conditions. The chemical structures of novel synthesized benzothiazole derivatives were affirmed by elemental analysis and different spectral data. The newly synthesized compounds were assessed as antibacterial agents against  Staphylococcus aureus  and  Escherichia coli  bacteria.

Synthesis of Novel Heterocycles Comprising Benzothiazole Moiety and Their Antimicrobial Evaluations