English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

A relatively shorter procedure for the synthesis of 3-amino-2-methyl-3 H -quinazolin-4-one ( 4 ) was developed. The subsequent condensation reaction of  4  with a variety of aldehydes afforded several novel Schiff bases ( 5a-r ) counting its molecular hybridization with the indole, thiophene, and quinoline pharmacophoric units. Full structural elucidation of all Schiff bases was conducted with the help of  1 H and  13 C NMR coupled with two-dimensional (HMBC, HSQC and COSY) techniques, and provides a reference point for the structural characterization of all the future synthesized scaffolds with a similar core structure. Furthermore, the antibacterial screening of all Schiff bases was undertaken using four Gram-negative strains,  Pseudomonas aeruginosa ,  Escherichia coli ,  Klebsiella pneumonia  and  Salmonella typhimurium , and two Gram positive-strains,  Staphylococcus aureus , and methicillin-resistant  Staphylococcus aureus  (MRSA). In general, several compounds showed activity against MRSA.

Synthesis, Structural Elucidation and Anti-Bacterial Evaluation of Fluorinated and Non-Fluorinated Schiff Bases of Quinazoline-4(3H)-One