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In this investigation, we continued to study the reaction of 6-bromo-3-(2-bromoacetyl)-2 H -chromen-2-one ( 2 ) with different active compounds in order to synthesize 1,3,4-thiadiazine  4 , benzofuran  6 , and naphthofuran  8  associated with coumarin moiety. On the other side, 6-bromo-3-(2-hydrazinylthiazol-4-yl)-2 H -chromen-2-one ( 9 ) allowed to condense with 6-bromo-3-acetylcoumarin ( 1 ), phthalic anhydride derivatives  11a,b , or 4-(4-substituted-benzylidene)-3-methyl-1-phenyl-1 H -pyrazol-5(4 H )-one  14a,b  to afford different (2 H -chromen-3-yl)thiazol-2-derivatives  10 ,  12a ,  12b ,  15a , and  15b , respectively. Six of the newly synthesized compounds were screened for their  in-vitro  antibacterial activity against Gram-positive bacteria, and Gram-negative bacteria. The results indicated that, compounds  4  and  10  showed strong inhibition activity toward  Enterococcus faecalis  (Gram-positive bacteria), while  12a  revealed strong activity toward  Pseudomonas aeruginosa  (Gram-negative bacteria).

Reactions and Antibacterial Activity of 6-Bromo-3-(2-Bromoacetyl)-2 H -Chromen-2-One