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An efficient and convenient method for the synthesis of a novel  N -acyl/aroyl spiro[chromane-2,4′-piperidin]-4(3 H )-one analogue was developed via two stage condensation of α-hydroxy acetophenone with 4-pipyridinone followed by amidation reaction with various acids in presence of amide coupling agent. These newly synthesized compounds exhibited excellent docking integrations with MDS 4.6 as well as good anti-fungal and anti-microbial activities.

polycyclic aromatic compounds

Synthesis, Biological Evaluation and Molecular Docking of Novel  N -Acyl/Aroyl Spiro[Chromane-2,4′-Piperidin]-4(3 H )-One as Potent Anti-Microbial Agents