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In this work, five component reactions are utilized for the production of quinazoline derivatives by utilizing the one-pot reaction of 3-hydroxyphthalaldehyde, ethylenediamine, alkyl bromides, electron deficient acetylenic compounds and ethyl bromoacetate in vicinity of Fe 3 O 4 /CuO nanocomposites as a high performance catalyst at environment temperature in water extract of  lettuce leaves  as green solvent. Also, water extract of  lettuce leaves  was used for synthesis of Fe 3 O 4 /CuO nanocomposites. The existing quinazoline core in the synthesized compounds caused to ability of antioxidation of synthesized quinazoline. For confirmation of this point, we are used DPPH radical trapping and ferric ion reducing power tests. Outcomes of these tests show that synthesized quinazolines have low DPPH radical trapping and good reducing ability of ferric ion. The excellent yield of reaction, green media and easy separation of product and catalyst are some benefits of this procedure.HighlightsWater extract of  Lettuce leaves  was used as solvent for the preparation of quinazolines as cyclic heteroaromatic systems.The present procedure avoids the use of toxic solvent.The present procedure runs in water extract of  Lettuce leaves  as a green media.This recoverable catalyst makes this protocol attractive and useful as an industrially viable and eco-safe solvent with high yields of products. Water extract of  Lettuce leaves  was used as solvent for the preparation of quinazolines as cyclic heteroaromatic systems. The present procedure avoids the use of toxic solvent. The present procedure runs in water extract of  Lettuce leaves  as a green media. This recoverable catalyst makes this protocol attractive and useful as an industrially viable and eco-safe solvent with high yields of products.

polycyclic aromatic compounds

Fe 3 O 4 /CuO Nanocomposite Promoted Green Synthesis of Functionalized Quinazolines Using Water Extract of  Lettuce Leaves  as Green Media: Study of Antioxidant Activity