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We have synthesized a new series of 7-chloroquinoline derivatives by a single step choro-amine coupling reaction. Compounds  3a–l  was tested for  in vitro  antitubercular and antimalarial agent. Compounds  3a  and  3 b  were more active than rifampicin against  M. tuberculosis  H37Rv and compound  3a  was more active against  P. falciparum  strain as compared to quinine. Furthermore, compounds  3b  and  3c  were found to possess excellent activity as compared to quinine. These compounds could be considered as a new broad spectrum antitubercular and antimalarial agent. All the synthesized compounds were confirmed by IR, Mass,  1 HNMR and  13 C NMR spectroscopy. Molecular docking studies were also done subsequently, using target, shikimate kinase (2IYZ) and hypoxanthine-guanine phosphoribosyltransferase (1BZY) enzyme to find the structural requirement for activity for these series of compounds.

Antitubercular, Antimalarial Activity and Molecular Docking Study of New Synthesized 7-Chloroquinoline Derivatives