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A series of new 6,8-dichloro-imidazo[1,2- a ]pyridine derivatives incorporating pyridine, thiazole, and pyrazole ring systems was synthesized. The synthetic strategy of imidazopyridinyl-pyridine hybrids  2  and  3  involves one pot reaction of the precursor 3-acetyl-6,8-dichloro-2-methylimidazo[1,2- a ] pyridine ( 1 ) with aldehydes, malononitrile, and/or ethyl cyanoacetate. Treatment of  1  with thiosemicarbazide and/or bromine followed by subsequent cyclization with ethyl bromoacetate, chloroacetone, phenacyl chloride, and/or thiourea was applied as synthetic routes for accessing the imidazopyridinyl-thiazole hybrids  5 ,  6,  and  8 – 10 . The reaction of  1  with dimethylformamide-dimethylacetal followed by subsequent treatment with hydrazine was employed to prepare the imidazopyridinyl-pyrazole motif  12 . The antibacterial potency of these imidazopyridine hybrids has been evaluated against some model bacteria. The results indicated that the imidazopyridine-thiazole hybrids revealed remarkable antibacterial activities.

Synthesis and Antibacterial Activity of New Imidazo[1,2- a ]pyridines Festooned with Pyridine, Thiazole or Pyrazole Moiety