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Sulfamic acid 2-Aminobenzothiazole-6-carboxylic acid functionalized Fe 3 O 4  nanoparticles as a novel organic-inorganic hybrid heterogeneous catalyst were manufactured and characterized by FT-IR, XRD, TGA, SEM, TEM, and VSM techniques. The catalytic activity of the magnetic catalyst was investigated through the one-pot synthesis of novel 3,4,5-trisubstituted furan-2(5 H )-ones derivatives from aryl aldehydes, 4-amino pyridine, and dimethyl acetylenedicarboxylate. The structure of all the new synthesized derivatives was determined by FT-IR,  1 H-NMR, and  13 C-NMR. The synthetic compounds exert moderate activity against both Gram-positive and Gram-negative bacteria and their effectiveness is higher against Bacillus subtilis. This green nano catalytic procedure has good reversibility and provides clean production in a short reaction time. These characters make the method practical and economical for researchers.

Preparation and Characterization of a Novel Magnetic Nano Catalyst for Synthesis and Antibacterial Activities of Novel Furan-2(5 H )-Ones Derivatives