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Present work involves the green and environmentally benign synthesis of 1,5-benzodiazepines using iodine as a catalyst and PEG-400 as a green solvent at room temperature that gives an excellent yield of products. All the synthesized compounds were screened for their anti-inflammatory, antioxidant, and antidiabetic activity. All the synthesized compounds showed excellent antioxidant activity against DPPH and H 2 O 2  radicals as compared to standard ascorbic acid and even more than standard for SOR and NO radicals. Compound  5h  showed the highest % anti-inflammatory activity i.e.,  80.73%  among the series that was comparable to standard diclofenac sodium whereas compound  5d  showed the highest antidiabetic activity i.e.,  60.46%  which was found potent as compared to standard acarbose.

polycyclic aromatic compounds

Green Synthesis, Molecular Docking,  In Silico  ADME and Biological Evaluation of Methoxy Substituted 1,5-Benzodiazepines as Potential Antioxidant, Anti-Inflammatory, and Antidiabetic Agents