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A new set of molecules was designed and synthesized by compilation of pharmacologically potential segments thiazole and quinoline bridged by 2-azetidinone as a linker in a single molecular skeleton. Structural analysis of synthesized molecules ( 5a-p ) was executed by IR,  1 H NMR,  13 C NMR, and mass spectroscopy techniques. Aforesaid compounds were analyzed for investigation of their antimicrobial capability against several bacterial and fungal strains. The synthesized compounds  5b ,  5f ,  5h ,  5i ,  5k , and  5l  were active against bacterial strains while compounds  5j  and  5k  were active against fungal strains. Synthesized compounds were found to be potential inhibitors against gram-negative bacterial strains  Escherichia coli  and  Pseudomonas aeruginosa , while the same were not effective against gram-positive strains of  Staphylococcus aureus  and  Streptococcus pyogenes . Compounds with electron-releasing substituents were active molecules against all fungal strains used in screening. Also, the influence of substituents on the antimicrobial activity of target molecules ( 5a-p ) was discussed. Molecular docking study against crucial microbial target β-Ketoacyl-acyl carrier protein (ACP) synthase III (FabH) could provide valuable insights into their plausible mechanism of action.

Synthesis, Antimicrobial Capability and Molecular Docking of Heterocyclic Scaffolds Clubbed by 2-Azetidinone, Thiazole and Quinoline Derivatives