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The preparation of pyrazinoquinazoline derivatives are performed in high yields by four component reactions of isoquinolin-3-ylmethanamine, α-haloketones, activated acetylenic compounds and ethyl bromoacetate in ionic liquid as green media at room temperature. In addition, due to having quinazoline core in the synthesized compounds, evaluation of antioxidant activity was performed by radical trapping by DPPH and reducing power of ferric ion experiments. As a result, synthesized compounds showed low radical trapping by DPPH and good reducing ability of ferric ion. The current procedure has the benefits for instance excellent yield of reaction, green media and easy separation of product.HighlightsIonic Liquid was used as solvent for the preparation of pyrazinoquinazoline as four cyclic heteroaromatic systems.The present procedure avoids the use of toxic solvent.The present procedure runs in ionic liquid as a green media.This recoverable ionic liquid makes this protocol attractive and useful as an industrially viable and eco-safe solvent with high yields of products. Ionic Liquid was used as solvent for the preparation of pyrazinoquinazoline as four cyclic heteroaromatic systems. The present procedure avoids the use of toxic solvent. The present procedure runs in ionic liquid as a green media. This recoverable ionic liquid makes this protocol attractive and useful as an industrially viable and eco-safe solvent with high yields of products.

Ionic Liquid as Green and Recyclable Solvent for the Synthesis of Pyrazinoquinazolines: Study of Antioxidant Activity