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In this research, we aimed to synthesize a new series of  C -glycosides that have thiazole-4, 5-diamine base.  C -glycosides  8  was prepared by coupling compound  7  with  D -glucose in the presence of iodine used as an oxidant/promoter dissolved in acetic acid and stirring at room temperature. Compound  8  was protected by reaction with acetic anhydride in the presence of pyridine gave compound  9 . Furthermore, cyclization compound  7  with hydrazine hydrate and  D -glucose gave the cyclic glycosides analogs  10 . The compound  7  was condensed with phenyl hydrazine hydrochloride and  D -xylose gave  C -glycoside  11 . The anticancer activity of the newly synthesized compounds was tested  in vitro  for their anticancer activities against human colorectal carcinoma (HCT-116), human prostate adenocarcinoma (PC-3), and human liver hepatocellular carcinoma (HepG-2) cell lines.

polycyclic aromatic compounds

An Efficient Procedure of Synthesis Acyclic  C -Glycosides of Thiazolo [4, 5- b ]Pyrazine and Imidazo[4,5-d]Thiazole with Expected Anti-Cancer Activities