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New series of 4-methyl-2-(4-substituted phenyl)-5-(4-((4-(4-substituted phenyl)-1H-1,2,3-triazol-1-yl)methyl)-1-phenyl-1H-pyrazol-3-yl)thiazole,  6a-t  and 4-(1,3-diphenyl-1 H -pyrazol-4-yl)-1-((1,3-diphenyl-1 H -pyrazol-4-yl)methyl)-1 H -1,2,3-triazole,  11a-o  derivatives have been synthesized by applying copper-catalyzed [3 + 2] cycloaddition reaction. The newly synthesized 1,3-thiazolyl-pyrazolyl-1,2,3-triazole ( 6a-t ) and bis-pyrazolyl-1,2,3-triazole ( 11a-o ) derivatives were screened for  in vitro  antimycobacterial activity against  M. Tuberculosis  H37Ra dormant and active and antibacterial activity against four pathogenic bacteria,  E. coli  (NCIM 2576),  P. flurescence  (NCIM 2059),  S. aureus  (NCIM 2602) and  B. subtilis  (NCIM 2162). Compounds  6a ,  6f ,  6j ,  11e  and  11m  showed good activity against  M tuberculosis  H37Ra Active strain, also compounds  6g ,  6h ,  11f ,  11n  and  11o  showed good activity against  M tuberculosis  H37Ra Dormant strain. Compounds  6b ,  6i ,  6l ,  6o, 6r, 11k ,  11l  and  11m  showed good activity against  B. subtilis  with IC 50  1.99-2.96 µg/mL. The antibacterial activity of thiazolyl-pyrazolyl-1,2,3-triazole and bis-pyrazolyl-1,2,3-triazole derivatives suggested that, these derivatives could lead to new compounds for treatment against bacterial infection.

Synthesis of New Thiazole and Pyrazole Clubbed 1,2,3-Triazol Derivatives as Potential Antimycobacterial and Antibacterial Agents