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The Fe 3 O 4 /ZnO/MWCNTs magnetic nanocomposites as a high performance organomettalic catalyst was employed for the preparation of naphthyridine derivatives in high yields  via  five component reaction of isoquinoline, dialkyl acetylenedicarboxylates or propiolates, α-haloketones, triphenyphophine and ammonium acetate in aqueous media at ambient temperature. The Fe 3 O 4 /ZnO/MWCNTs MNCs were synthesized using ionic liquid [OMIM]Br as a stabilizer and soft template. As well Fe 3 O 4 /ZnO/MWCNTs MNCs show a good improvement in the yield of the product and showed significant reusable ability. Due to having isoquinoline core, we investigate antioxidant property of some synthesized compounds by diphenyl-picrylhydrazine (DPPH) radical trapping and power of ferric reduction experiment. Furthermore, the disk diffusion test on Gram positive and negative bacteria are utilized for investigation of antimicrobial activity of some naphthyridines. The achieved outcomes of this experiment demonstrate that these synthesized compounds could prevent from growth of bacteria. Short time of reaction, high yields of product, easy separation of catalyst and products are some benefits of this process.HighlightsGreen chemistry is the use of a set of principles to reduce or eliminate the use or generation of unsafe materials in the design, fabrication and applications of chemical products. Among solvents, water is a green solvents and very suitable for performing organic reaction.The present procedure avoids the use of toxic solvent.Compounds containing a naphthyridine scaffold are a small class of bispyridine structures identified in various living organisms (plants, sponges, tunicates, bryozoans). These natural products usually possess variant biological activities, which make them attractive lead compounds for further drug discovery. Green chemistry is the use of a set of principles to reduce or eliminate the use or generation of unsafe materials in the design, fabrication and applications of chemical products. Among solvents, water is a green solvents and very suitable for performing organic reaction. The present procedure avoids the use of toxic solvent. Compounds containing a naphthyridine scaffold are a small class of bispyridine structures identified in various living organisms (plants, sponges, tunicates, bryozoans). These natural products usually possess variant biological activities, which make them attractive lead compounds for further drug discovery.

Reusable Fe 3 O 4 /ZnO/MWCNTs Magnetic Nanocomposites Promoted Synthesis of New Naphthyridines