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In consideration of green and efficient organic chemical methodology, we reported here a green, an efficient and convenient procedure for synthesis of 3-aryl-2,3-dihydro-1,3,4-thiadiazoles based on benzofuran as well as chromone moieties, using the grinding technique. Condensation of 1-(4,7-dimethoxybenzofuran-5-yl)ethan-1-ones  2 ,  3 ; 7-hydroxy-5-methoxy-2-methyl-4-oxo-4 H -chromene-6-carbaldehyde ( 4 ); and 4-oxo-4 H -chromene-3-carbaldehydes  10a–c  with alkyl hydrazine carbodithioates followed with some hydrazonoyl halides  7a–g  under grinding and solvent-free condition led to the formation of the targeted 3-aryl-2,3-dihydro-1,3,4-thiadiazoles  8a–g ,  9a,b , and  12a–f , correspondingly. Structures of the synthesized compounds were clarified based on their elemental analyses and spectral data. Eleven of the entire target compounds were selected for anticancer activity against 60 human cancer cell lines at a single dose (10‾ 5  M) by the National Cancer Institute (NCI, Bethesda, USA).

Eco-Friendly Synthesis of 3-Aryl-2,3-dihydro-1,3,4-thiadiazoles Based on Benzofuran and Chromone Moieties