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One-pot synthesis of quinolinyl amine nitriles,  8,  was accounted from quinoline-3-carbaldehyde,  7,  and amines (benzylic, aromatic, aliphatic, or hetero-aromatic) using Zn(CN) 2 /trifluoroethanol (TFE) system, an eco-friendly, and ambient protocol. Antidiabetic, anti-inflammatory, antioxidant, and molecular docking studies of  8a–l  revealed moderate-to-good activity.

One-Pot Synthesis of Quinolinyl Amino Nitriles and Their Antidiabetic, Anti-inflammatory, Antioxidant, and Molecular Docking Studies