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A novel series of Schiff base indolyl-pyridine derivatives containing, thiazolidinone and azetidinone moieties were synthesized. The structure of these recently integrated compounds was asserted by their IR,  1 H,  13 C NMR, mass spectral data as well as elemental analysis. These compounds were likewise evaluated for in vitro antimicrobial, antioxidant, anti-TB and anticancer activities. The structure-activity relationships of compounds were also established. Among which compound  4a  has dynamic bactericidal activity against  S. aureus  and  B. subtilis,  compound  5a  applied extraordinary action against  E. coli  and  K. pneumonia  and fungicidal activities. Antioxidant studies revealed that  4c ,  5 b  and  5e  showed noteworthy antioxidant activities. While, anticancer movement demonstrated that compound  4e  was most strong toward all attempted cancer cell lines. Compound  5e  apparently was generally powerful against H37Rv strain  M. tuberculosis . Further, to understand the binding modes of the incorporated compounds molecular docking contemplates were performed using crystal structure of mycobacterium smegmat complexed with SQ109 (PDB ID: 6AJG, resolution: 2.604 Å).

Synthesis, Biological Evaluation and Docking Studies of Some New Indolyl-Pyridine Containing Thiazolidinone and Azetidinone Analogs