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The new compounds 6-methyl-8-morpholino-2 H  pyrimido[5’,4’:5,6][1,4]thiazino[3,2 e ][1,2,4]triazin-3(5 H )-one  (3a)  and 6-methyl-8-(piperidin-1-yl)-2 H pyrimido[5’,4’:5,6][1,4]thiazino[3,2- e ][1,2,4]triazin-3(5 H )-one  (3b)  were obtained from cyclocondensation of 6-bromo-1,2,4-triazine-3,5(2 H ,4 H )-dione  (1)  with appropriate 5-amino-6methylpyrimidine-4-thiol ( 2a, b)  in dimethylformamide and in the presence of potassium carbonate under reflux. Reaction of compounds  (3a, b)  with phosphorous oxychloride gave 4-(3-chloro-6-methyl-5 H -pyrimido[5’,4’:5,6][1,4]thiazino[3,2- e ][1,2,4]triazin-8-yl)morpholine  (4a)  and 3-chloro-6-methyl-8-(piperidin-1-yl)-5 H -pyrimido[5’,4’:5,6][1,4]thiazino[3,2- e ][1,2,4]triazine  (4b) . Nucleophilic substitution of chlorine atom of compounds  (4a, b)  with typical secondary amines in DMF and K 2 CO 3  produced the new derivatives of the 3,8-disubstituted-5 H- pyrimido[5’,4’:5,6][1,4]thiazino[3,2- e ][1,2,4]triazine ring systems  (5a–f) . All the synthesized products were characterized and confirmed by their spectroscopic and microanalytical data.

Synthesis of A Novel Heterocyclic System of 3,8-Disubstituted-5 H- Pyrimido[5’,4’:5,6][1,4]Thiazino[3,2- e ][1,2,4]Triazine