English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Antimicrobial chemotherapy is the clinical application of antimicrobial agents to treat infectious disease. A new series of 3,6-disubstituted- and 2,3,6-trisubstitutedquinoxalines have been synthesized by appropriate methods. All test compounds have been evaluated for  in vitro  antimicrobial activity. Further investigation using MIC experiment was performed; It appears that, compound  14c  has higher broad-spectrum antibacterial activity (MIC= 0.01–0.24 ug/ml) than the reference drug, streptomycin (MIC= 0.03–0.97 ug/ml). As well, it elicited remarkable antifungal activity than the reference drug clotrimazole against almost all the selected strains. Moreover, docking study of the most active compounds into MurF active site has confirmed their binding affinity to MurF.

Design and Synthesis of 3,6-Disubstituted- and 2,3,6-Trisubstitutedquinoxalines: Docking and In Vitro Antimicrobial Study