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New fluorine compounds bearing 4-amino-1,2,4-triazino[4,3-b] − 1,2,4-triazin-8-one (4) and the related derivatives  N- acyl,  N -alkyl, and Schiff base have been obtained from condensation of 6(2′-aminophenyl-3-thioxo-1,2,4-triazin-5-one (1) with 4-fluorobenzaldehyde followed by treated with 4-tollyl sulfonic acid hydrazide and finally undergo ring closure reaction with chloro-acetonitrile to give the starting  4 . The presence of free amino-group of  4  confirmed from acylation  5 , aroylation  6  and alkylation  7–9 . A simple addition of n-butyl-thiophenol to Schiff base 4 gave a type of thioethers  10  and  11 , respectively. The structure of the targets has been established from then elemental analysis and spectral measurements. The compounds  4–12  evaluated as CDK2 inhibitors of tumor cell, were the activity in the order of 12 &gt; 11 &gt; 10 &gt; 3&gt;9 &gt; 8&gt;5 &gt; 2.

polycyclic aromatic compounds

Synthesis and Biological Evaluation of New Fluorine Compounds Bearing 4-Amino-1,2,4-triazino[4,3-b]-1,2,4-triazin-8-one and the Related Derivatives as CDK2 Inhibitors of Tumor Cell