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For the first time, medicinally substantial amidoalkyl naphthoquinones are prepared  via  an eco-friendly, appropriate, and straightforward protocol accomplishing through the one-pot multicomponent reaction of aromatic aldehyde, 2-hydroxy-1,4-naphthoquinone (lawsone) and benzamide or acetamide at 80 °C under solvent-free condition in presence of  p -TSA as a catalyst. It is awaited that our methodology to be effective in the combinatorial synthesis of bioactive compounds; because amidoalkyl naphthoquinone derivatives are a very important category of naturally occurring compounds. The structures of synthesized compounds were characterized by  1 H,  13 C NMR, mass spectroscopy and elemental analysis.

The First Effort for the Preparation of Amidoalkyl Naphthoquinone Skeleton Based on Solvent-Free Multicomponent Reaction