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A new terrein dimer named lichtheicol A ( 1 ) and a new meroterpene named lichtheiterpene A ( 2 ), were isolated from the mangrove endophytic fungus  Lichtheimia  sp. J2B1, together with 10 known compounds ( 3–12 ). The planar structures and absolute configurations of  1  and  2  were established by a combination of extensive spectroscopic data analyses and electronic circular dichroism (ECD) calculations. Compounds  4  and  5  exhibited marked inhibitory effects against butyrylcholinesterase (BuChE) with IC 50  values of 0.71 and 0.53 μM, respectively.

A new terrein dimer and a new meroterpene from the mangrove endophytic fungus Lichtheimia sp.