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Two new alkaloids, spongimides A ( 1 ) and B ( 2 ), along with five known ones ( 3 – 7 ), were isolated from the marine sponge  Spongia  sp. The structures of  1  and  2  were determined by the spectroscopic methods (UV, IR, MS, and NMR) and X-ray diffraction analysis. Compounds  1 ,  3 , and  4  were the first examples of 2,4-imidazolidinediones isolated from this genus. In addition, the cytotoxic and antibacterial activities of compounds  1  and  2  were also evaluated.

Spongimides A and B, two new alkaloids from the marine sponge Spongia sp.