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TMEM16A regulator is an important tool to study the physiological functions and pathogenesis related to TMEM16A. In the present study,  trans-ε -viniferin (TV) was identified as a TMEM16A inhibitor with inhibitory activity against TMEM16A mediated Cl −  currents, which was reversible, without affecting intracytoplasmic Ca 2+  concentration and TMEM16A protein expression. TV inhibited intestinal peristalsis and prolonged gastrointestinal transport time. TV could inhibit autonomic and E act -stimulated intestinal contractility, and was equally effective in ACh- and HA-induced high contractile states. The results indicate that TV significantly inhibits the intestinal smooth muscle contraction, which may be applied in the treatment of TMEM16A-related intestinal dynamic abnormalities.

Trans-ε-viniferin as an inhibitor of TMEM16A preventing intestinal smooth muscle contraction