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Echinacoside (ECH) is the main compound of  Cistanche deserticola , which possesses antioxidant, antitumor, antifatigue, and anti-inflammatory properties. The present study investigated the protective effects of echinacoside on type 2 diabetes mellitus (T2DM)-induced injury in T2DM injury db/db mice model and insulin-resistant LO 2  cell model. The results demonstrated that ECH probably alleviated T2DM-induced injury by mediating the AKT pathway, which provided a new direction for the treatment of T2DM-induced injury.

Echinacoside exerts its protective effects in a type 2 diabetes mellitus injury model via the AKT pathway