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Two new scalarane sesterterpenes, hyrtiosins F and G ( 1  and  2 ), along with two known related compounds, hyrtiosin D and sesterstatin 6 ( 3  and  4 ), were isolated from the Hainan marine sponge  Hyrtios erecta.  The structures of new compounds  1  and  2  were determined by detailed analysis of 1D and 2D NMR spectra and by comparison of the spectroscopic data with those reported in the literatures.

Hyrtiosins F and G, two new scalarane sesterterpenes from the South China sea sponge Hyrtios erecta