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A series of 4-(propargyloxy) benzenesulfonamide derivatives with different substituents on the benzene ring were synthesized and evaluated for their insecticidal activity. Some of the compounds showed good insecticidal activity against  Mythimna separata , and the LC 50  value of the most active compound  B2.5  was 0.235 mg/ml. Ultrastructural changes in the midgut epithelial cells of  Mythimna separata  were observed using transmission electron microscopy, and severe structural damage was found in microvilli, mitochondria and rough endoplasmic reticulum. It indicates that the possible site of action of these benzenesulfonamides is the cytoplasmic membrane and endomembrane system of the midgut epithelial cells. The above provides a basis for the development of novel insecticidal active compounds with a novel mechanism of action.

Synthesis and insecticidal activities of 4-(propargyloxy) benzenesulfonamide derivatives