English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Twenty-two metabolites were isolated from  Penicillium  sp. CPCC 401423 cultured on rice. The structures of all compounds were elucidated mainly by MS and NMR analysis as well as the necessary CD experimental evidence, of which penicillidione A ( 1 ), penicillidione B ( 2 ), ( E )-4-[(4-acetoxy-3-methyl-2-butenyl)oxy]phenylacetic acid ( 3 ), ( S )-2-hydroxy-2-{4-[(3-methyl-2-butenyl)oxy]phenyl} ( 4 ), ( S )-4-(2,3-dihydroxy-3-methyl-butoxy)phenylacetic acid ( 5 ), ( E )-4-[(3-carboxy-2-butenyl)oxy]benzoic acid ( 6 ), ( Z )-4-[(4-hydroxy-3-methyl-2-butenyl)oxy]benzoic acid ( 7 ), open-cycled N-demethylmelearoride A ( 12 ), and penostatin M ( 16 ) were identified as new compounds. The cytotoxic activity against human pancreatic carcinoma cell line MIA PaCa-2a was detected. Among them, compounds  13 – 15  and  22  displayed significant cytotoxicity against MIA-PaCa-2 cells with IC 50  values of 8.9, 36.5, 31.8, and 22.3 µM, respectively (positive control gemcitabine IC 50  65.0 µM).

Metabolites from the plant endophytic fungus Penicillium sp. CPCC 401423 and their cytotoxic activity against MIA PaCa-2 cells