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A new furostane saponin, ramosaponin ( 1 ), and four known furostane saponins, protodioscin ( 2 ), dehydrotomatoside ( 3 ), (25  R )-26- O -( β -D-glucopyranosyl)-furost-5-ene-3 β ,22 α ,26-triol 3- O - β -D-glucopyranosyl-(1→4)- β -D-galactopyranoside ( 4 ), and anguivioside A ( 5 ) were isolated from the methanol extract of  Allium ramosum  seeds. Their structures were identified based on spectroscopic evidence and comparison with those reported in the literature. All compounds were evaluated for reduction of lipid accumulation in HepG2 cell line. As a result, compound  1  showed significant lipid accumulation inhibitory activity with an IC 50  value of 64.32 ± 3.87 µM.

One new furostane saponin from Allium ramosum and lipid accumulation inhibitory activity