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Four new ionones and ionone glycosides ( 1 – 4 ) were isolated from the whole plant of  Rehmannia piasezkii  Maxim. Their planar structures as well as absolute configuration were confirmed via spectroscopic analysis, ECD calculation, and X-ray crystallography. Compounds  1 – 4  were tested for their cytotoxicity against five human tumor cell lines and ability to inhibit LPS-activated NO production in the BV2 cell line.

Four ionones and ionone glycosides from the whole plant of Rehmannia piasezkii