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A new polyketide derivative containing a 3-hydroxydecanoic acid ester moiety, penicipurate A ( 1 ), was purified from the solid cultures of the fungus  Penicillium purpurogenum , a fungal strain endophytic in the leaves of  Edgeworthia chrysantha . The structure of  1  was established by spectroscopic methods, including UV, IR, HRESIMS, 1D, and 2D NMR and  13 C NMR chemical shifts calculations coupled with DP4+ analysis, as well as the chemical degradation method. Compound  1  showed moderate inhibitory activity against pancreatic lipase (PL) with an IC 50  value of 9.61 ± 1.42 µM.

Penicipurate A, a new polyketide derivative from the endophytic fungus Penicillium purpurogenum