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A pair of novel trimeric indole alkaloid enantiomers [(±)- 8 ], five new bisindole alkaloids [ 4–7  and (±)- 9 ], and three pairs of new monomeric indole alkaloid enantiomers [(±)- 1– (±)- 3 ], together with seven known alkaloids ( 10–16 ), were isolated from the bark of  Acacia confusa . Their structures were determined on the basis of spectroscopic methods, especially by NMR data analyses combined with single-crystal X-ray diffraction and electronic circular dichroism analyses. Compounds  4  and  11–16  exhibited significant antinociceptive activities in an acetic acid-induced writhing test. Compounds (+)- 9  and (−)- 9  displayed anti-inflammatory activities through the inhibition of the NF-κB pathway, with inhibitory rates of 68.9% and 59.5%, respectively, at a concentration of 10  µ M.

Indole alkaloids from the bark of Acacia confusa and their potential antinociceptive and anti-inflammatory activities