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A phytochemical investigation on the 90% ethanol extract of the leaves of  Croton lachnocarpus  Benth. led to three new  ent -abietane diterpenoids, 7 β ,15-dihydroxy- ent -abieta-8,11,13-trien-3-one ( 1 ), 2 β ,15-dihydroxy- ent -abieta-8,11,13-triene ( 2 ), and 7 β ,13 α ,15-trihydroxy- ent -abieta-8(14)-en-3-one ( 3 ). Structural elucidation of all the compounds were performed by spectral methods such as 1 D and 2 D ( 1 H -1 H COSY, HMQC, NOESY and HMBC) NMR spectroscopy, in addition to electronic circular dichroism (ECD) spectra. The isolated compounds were tested  in vitro  for cytotoxic activity against 6 tumor cell lines. As a result, compound  3  exhibited some cytotoxicities against all the tested tumor cell lines with IC 50  value less than 30 μM.

Cytotoxic ent-abietane diterpenoids from the leaves of Croton lachnocarpus Benth.