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Two new tricyclic pyridone analogues, fusapyridons C ( 1 ) and D ( 2 ), were isolated along with structurally related known compounds  3  −  5  from the entomopathogenic fungus,  F. avenaceum  SYKC02-P-1. The structures of compounds  1  and  2  were elucidated by analyzing the spectral data of UV, 1 D and 2 D NMR as well as HRESIMS. The absolute configurations of fusapyridons C and D were established by means of single crystal X-ray diffraction and electronic circular dichroism calculation. And antitumor testing of all the isolates showed that compounds  4  and  5  exhibited significant inhibitory activity against the human prostate cancer cells (PC-3 cell lines) with IC 50  values of 2.76 and 1.86 μM, respectively.

Antitumor potential of tricyclic pyridone analogues from an entomopathogenic fungus, Fusarium avenaceum SYKC02-P-1