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Three new chromanes, malloapeltas J–L ( 1 – 3 ), and one new flavone  C -glycoside, malloflavoside ( 4 ), together with four known compounds, apigenin 6- C - β -D-xylopyranosyl-8- C - α -L-arabinopyranoside ( 5 ), apigenin 6- C - β -D-glucopyranosyl-8- C - α -L-arabinopyranoside ( 6 ), apigenin 7- O - β -D-apiofuranosyl-(1→2)- β -D-glucopyranoside ( 7 ), and acantrifoside E ( 8 ) were isolated from the methanol extract of the leaves of  Mallotus apelta . Their chemical structures were determined using spectroscopic methods, including 1D, 2D NMR, and HR-ESI-MS methods. All the isolated compounds were evaluated their cytotoxic activity against human prostate cancer (PC-3) and human breast cancer (MCF-7) cells, but none of them showed cytotoxicities on both human cancer cell lines.

Three new chromanes and one new flavone C -glycoside from Mallotus apelta