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Four minor undescribed terpenoids, including a monoterpenoid ( 1 ) and three triterpenoids ( 3 ,  6  and  7 ), together with 26 known terpenoids were isolated from the stems and twigs of  Rhododendron Ovatum . Their structures were identified by extensive spectroscopic analyses and electronic circular dichroism (ECD) techniques. Compound  10  showed excellent cytotoxicity against human colon cancer cell (HCT-116) with IC 50  value of 2.56 μM. Compounds  9  and  19  exhibited partly inhibitory effects on nitric oxide production stimulated by lipopolysaccharide-induced neuroinflammation in microglia cells at 10 μM with inhibition ratios of 39.70% and 28.08%, respectively.

Minor terpenoids from the stems and twigs of Rhododendron ovatum